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Transcription & RNA Synthesis
Used in IVT systems to generate high-quality and modified mRNA with improved performance
pseudouridine can reduce innate immune recognition compared with unmodified uridine and improve RNA stability and translational performance
TBDMS offers excellent stability for protecting 2’-hydroxyl of ribonucleosides during acid detritylation and oxidation steps
DMT-2'-O-Me-A(Bz)-CE Phosphoramidite Amount/Package:0.5g / 30mL screwed bottle-28 Transcription & RNA SynthesisDMT 2' O Me A(Bz) CE Phosphoramidite is a 2' OMe phosphoramidite monomer used for solid phase oligonucleotide synthesis. It contains a 5' dimethoxytrityl (DMT) protecting group for 5' hydroxyl protection, a benzoyl (Bz) base protecting group on adenine, a cyanoethyl (CE) protecting group on phosphite, and a 2' O methyl (2' OMe) ribose modification The 2' OMe modification improves duplex stability, reduces immunogenicity, and significantly increases
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